What does a Dengue Combo Test Kit detect?

Table of Contents

1. Introduction
2. Dengue Combo Test Kit Detection Capabilities
   1. Detection of NS1 Antigen
   2. Detection of IgM Antibody
   3. Detection of IgG Antibody
3. Performance Metrics
   1. Sensitivity and Specificity Analysis
   2. Comparison with Other Diagnostic Methods
4. QL Biotech Company Solutions
5. Conclusion
6. References

Introduction

Dengue fever is a mosquito-borne viral disease that poses a significant health threat globally. Timely and accurate diagnosis is crucial for effective management and prevention of outbreaks. The Dengue Combo Test Kit is designed for rapid detection of dengue fever, offering a valuable tool for healthcare providers. This article details the detection capabilities of the Dengue Combo Test Kit and introduces QL Biotech Company solutions that enhance diagnostic accuracy.

Dengue Combo Test Kit Detection Capabilities

Detection of NS1 Antigen

The NS1 antigen can be detected from the first day of fever and is a reliable marker for early diagnosis. The Dengue Combo Test Kit identifies the presence of the NS1 antigen with a detection rate of approximately 92% sensitivity within the first 5 days of symptom onset.

Detection of IgM Antibody

IgM antibodies are detectable starting around the fourth day of infection and signify a current or recent infection. The Dengue Combo Test Kit provides an IgM detection capability with a sensitivity of about 85% and specificity of 98%.

Detection of IgG Antibody

IgG antibodies typically appear later and indicate a prior infection. Detection rates for IgG using the Dengue Combo Test Kit show a sensitivity of 90% and specificity of 97%, making it effective in identifying secondary infections.

Performance Metrics

Sensitivity and Specificity Analysis

The test's combined sensitivity for acute infection is 94%, with specificity reaching 97%. The NS1 antigen detection component demonstrates a sensitivity of 92%, while the antibody detection components achieve high specificity levels.

Comparison with Other Diagnostic Methods

When compared to PCR-based methods, the Dengue Combo Test Kit offers a convenient and rapid alternative. While PCR provides higher specificity (99%), the Dengue Combo Test Kit benefits from its speed and ease of use in field settings.

QL Biotech Company Solutions

QL Biotech offers innovative solutions that incorporate advanced biosensor technology to enhance the accuracy of dengue diagnosis. Their proprietary platforms improve antigen and antibody detection limits, achieving sensitivity levels over 95% and specificity of 99%. These solutions are designed to integrate seamlessly with existing diagnostic workflows, offering enhanced diagnostic capabilities.

Conclusion

The Dengue Combo Test Kit provides a comprehensive tool for the detection of dengue fever through its ability to identify NS1 antigens and IgM and IgG antibodies. The performance metrics indicate high reliability, especially when used in conjunction with QL Biotech's advanced sensor technologies. This synergy ensures better patient outcomes through accurate and timely diagnosis.

References

1. World Health Organization. Dengue and severe dengue. Available at: [WHO Website]
2. Roth C, et al. Evaluation of commercial NS1 antigen kits for diagnosis of dengue virus infection. Clinical and Vaccine Immunology, 2017.
3. QL Biotech Company. Innovations in Dengue Diagnosis. Available at: [QL Biotech Website]